What accumulates in the respiratory system as a result of whooping cough?

Whooping cough, also known as pertussis, is a highly contagious respiratory disease caused by the bacterium Bordetella pertussis. One of the hallmarks of this disease is the excessive coughing, which can lead to the accumulation of mucus in the respiratory system. During the infection, the bacteria cause inflammation in the lining of the airways, which results in the production of thick mucus. This increased mucus production is a defense mechanism intended to trap pathogens and irritants; however, it also makes clearing the airways difficult, leading to the characteristic coughing fits associated with whooping cough. The cough exacerbates the production and retention of mucus, further complicating airflow and breathing.

In contrast, while oxygen and carbon dioxide are gases involved in respiration, they do not accumulate specifically due to whooping cough. Blood may not be directly relevant to the accumulation seen in this condition, typically not being a component that gathers in the airways during this type of infection. Thus, the correct answer highlights the significant role of mucus in the pathophysiology of whooping cough, emphasizing its relevance in understanding the disease's impact on the respiratory system.